A Novel Bioactive Molecule Derived from Marine Resources and Their Anti-HIV (Human Immunodeficiency Virus Type - 1) Activity
Ulaganathan Arisekar*
Dept. of Fish Quality Assurance and Management, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, Tamil Nadu (628 008), India
Kumaresan Ajith Kumar
Dept. of Fish Quality Assurance and Management, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, Tamil Nadu (628 008), India
Robinson Jeya Shakila
Dept. of Fish Quality Assurance and Management, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, Tamil Nadu (628 008), India
Rajendran Shalini
Dept. of Fish Quality Assurance and Management, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, Tamil Nadu (628 008), India
Balasubramanium Sivaraman
Dept. of Fish Quality Assurance and Management, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, Tamil Nadu (628 008), India
DOI: NIL
Keywords: Anti-HIV activity, Bioactive components, HIV drugs, Marine sponges
Abstract
The current treatment for Human immunodeficiency virus (HIV)-1 infection is antiretroviral therapy (ART). So, it's important to keep looking for compounds with an anti-HIV-1 activity that could be used to make an alternative, cost-effective, side effect therapy to ART. The therapeutic potential of natural compounds and their derivatives against HIV makes them an excellent alternative. Zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta) that inhibits the reverse transcriptase of the virus, is currently accessible as an anti-HIV-1 drug derived from natural substances. The antiviral drug isoxazole was the first to be approved to treat HIV infection. Bevirimat (found in Syzygium claviflorum) and calanolide A (found in Calophyllum sp.) are both antiviral agents that work by inhibiting the reverse transcription process. Natural substances with the anti-HIV-1 activity that can be evaluated to develop new therapeutic strategies to control the HIV pandemic were the focus of this article.
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Reference
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