Glucose Regulation by the Action of Insulin Signaling Pathway
Debanjana Saha*
Dept. of Biotechnology, Centurion University of Technology and Management, Jatni, Bhubaneshwar, Odisha (752 050), India
Diptanu Datta
Dept. of Plant pathology, Odisha University of Agriculture and Technology, Bhubaneshwar, Odisha (751 003), India
DOI: NIL
Keywords: Glycogen synthase, Glycogen, Glucose, Insulin
Abstract
As we all know if we consume much of carbohydrate rich food, it may increase the sugar (glucose) levels in our blood which in turn may cause severe damage to our health. In this case Insulin, a hormone synthesized from beta cells of islets of Langerhans comes into play by regulating the glucose levels in our body through Insulin signaling pathways where Insulin acts as a ligand molecule by binding to its two receptor subunits i.e. alpha & beta respectively where insulin binds to the later subunit by autophosphorylation and as a result of this tyrosine molecules becomes the attachment point for other proteins such as IRS-1 (insulin receptor substrates). Phosphorylation in the IRS1 or IRS2 initialtes the PI3k/AKT and Ras-Raf-MEK-MAPK signaling pathway. Our article deals in detail on how insulin regulates the glucose level by various signaling pathway.
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Reference
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