Y-Family DNA Polymerases and Translesion Synthesis
Mandeep Singh*
Dept. of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, Punjab (141 004), India
Anuj Choudhary
Dept. of Botany, Punjab Agricultural University, Ludhiana, Punjab (141 004), India
DOI: NIL
Keywords: DNA polymerases, DNA repair, Error-prone replication, Translesion synthesis
Abstract
DNA polymerases are specialized in the synthesis and repair of the genetic material. Y-family DNA polymerases lie at the heart of the mutagenesis process, a process commonly known as translesion synthesis. Y-family DNA polymerases have special characteristics of synthesizing the bases on damaged DNA. Translesion synthesis (TLS) is a process carried out by special polymerases for the prevention of cell death. This article mainly emphasizes the process carried out by DNA polymerases for prevention of cell death viz., TLS along with their necessities, and also for error-prone replication.
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Reference
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